Highlights • Following transplantation, spermatogonial stem cells follow stochastic clone dynamics • Most initially settled stem cells are lost through chance differentiation and death • Donor cell differentiation can be suppressed using a retinoic acid synthesis inhibitor • Transient differentiation block boosts repopulation and restores fertility of the host Summary A remarkable feature of tissue stem cells is their ability to regenerate the structure and function of host tissue following...
