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Functional Variants in the Chromosome 4q21 Locus Contribute to Allergic Rhinitis Risk by Modulating the Expression of N‐Acylethanolamine Acid Amidase (NAAA)

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By Yang Yie Sio, Ping Shi, Fook Tim Chew, Yee‐How Say
| Wiley Online Library Verified
Background Previous haplotype‐based association studies identified chromosome 4q21 as an allergic rhinitis (AR) susceptibility locus, however, the functional role of 4q21 single nucleotide polymorphisms (SNPs) on AR risk remains unclear. Objective To investigate the functional effect of 4q21 SNPs on AR risk by conducting cohort‐based functional genomics and genetic association analyses.
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