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Yehuda G Assaraf on Muck Rack

Yehuda G Assaraf

Israel
As seen in: Nature, BioRxiv
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Articles

Targeted deprivation of STAT6 sensitizes acute lymphoblastic leukemia cells to cytarabine in vivo and in vitro: clinical implications - Cell Death & Disease

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By Yehuda G Assaraf, Hui Li
| Nature Verified
Abstract Chemotherapy is the leading treatment for acute lymphoblastic leukemia (ALL). However, many ALL patients eventually develop relapses, the treatment of which remains a major challenge due to their chemoresistance phenotype. As a step towards this end, we here uncovered that relapsed ALL specimens exhibit a significantly lower expression of STAT6 but not of other STATs, when compared with their paired diagnosis specimens.
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Therapeutic targeting de novo purine biosynthesis driven by β-catenin-dependent PPAT upregulation in hepatoblastoma - Cell Death & Disease

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By Ming Ding, Liang Zhu, Yehuda G Assaraf, Bin-Bing S. Zhou, Song Gu
| Nature Verified
Abstract De novo purine biosynthesis (DNPS) was previously shown to be aberrantly activated in many cancers. However, the activity of DNPS pathway and its underlying regulatory mechanism in hepatoblastoma (HB) remain poorly understood. Herein, we discovered that the expression of PPAT, the rate-limiting enzyme in DNPS, was markedly upregulated in HB, leading to an augmented purine flux via DNPS, thereby promoting both HB cell proliferation and migration.
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Integration of transcription regulation and functional genomic data reveals lncRNA SNHG6's role in hematopoietic differentiation and leukemia

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By Joshua Hazan, Raziel Amador, Tamar Lahav, Yehuda G Assaraf
| BioRxiv
Abstract Background Long non-coding RNAs (lncRNAs) are pivotal players in cellular processes, and their unique cell-type specific expression patterns make them attractive biomarkers and therapeutic targets. Yet, the functional roles of most lncRNAs remain enigmatic.
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