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Yepy Rustam

As seen in: Nature
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Articles

BAK core dimers bind lipids and can be bridged by them

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By Angus D. Cowan, Nicholas Smith, Jarrod J. Sandow, Yepy Rustam
| Nature Verified
Abstract BAK and BAX are essential mediators of apoptosis that oligomerize in response to death cues, thereby causing permeabilization of the mitochondrial outer membrane. Their transition from quiescent monomers to pore-forming oligomers involves a well-characterized symmetric dimer intermediate. However, no essential secondary interface that can be disrupted by mutagenesis has been identified.
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Evaluation of ultraviolet photodissociation tandem mass spectrometry for the structural assignment of unsaturated fatty acid double bond positional isomers

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By Gavin Reid, Mengxuan Fang, Yepy Rustam, Michelle Palmieri
| link.springer.com
Abstract Fatty acids are a major source of structural diversity within the lipidome due to variations in their acyl chain lengths, branching, and cyclization, as well as the number, position, and stereochemistry of double bonds within their mono- and poly-unsaturated species. Here, the utility of 193 nm UltraViolet PhotoDissociation tandem mass spectrometry (UVPD-MS/MS) has been evaluated for the detailed structural characterization of a series of unsaturated fatty acid lipid species.
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