Yerzhan Abdrakhmanov on Muck Rack

Yerzhan Abdrakhmanov

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Uncovering evolutionarily remote and highly potent antimicrobial peptides with protein language models - Nature Biomedical Engineering

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By Qinze Yu, Hongbin Liu, Haimei Shi, Junbo Shen, Chunhe Zhang, Zhihang Dong, Licheng Zong, Longlong Si, Lei Dai, Yu Li, Yerzhan Abdrakhmanov
| Nature
Abstract Identifying evolutionarily remote antimicrobial peptides (AMPs) is crucial for discovering underexplored clinical candidates to combat antibiotic resistance. Existing experimental and computational methods are limited by their reliance on sequence identity to known AMPs, missing distant homologues. Here we introduce HMD-AMP, a protein language model-based approach for AMP discovery.
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