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Cancers | Free Full-Text | Transcriptomic Maps of Colorectal Liver Metastasis: Machine Learning of Gene Activation Patterns and Epigenetic Trajectories in Support of Precision Medicine
1. Introduction Liver metastasis, linked with poor prognosis, is a common occurrence in various cancers, including colorectal cancer (CRC), pancreatic cancer, breast cancer, melanoma, and lung cancer. In CRC, the liver is the primary site of metastasis owing to the anatomical and vascular connections between the colorectal regions and the liver [1]. Such metastases pose a significant challenge for clinical intervention and represent a major cause of CRC-related mortality.
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