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Articles by Yi Luan
Construction of molecular fans in metal-organic framework to overcome diffusion resistance for trace benzene capture
Abstract Molecular size-matched pores of adsorbents provide strong adsorptive forces for benzene, but high diffusion resistance. Overcoming the diffusion resistance within molecular size-matched pores is essential to efficient capture of trace benzene from indoor air or industrial exhaust gas, but challenging.
100-Fold Reductivity Enhancement of Nanoscale Zero-Valent Iron After 1-Year Aging in Water via Regulating Corrosion Reactions
Conflicts of Interest The authors declare no conflicts of interest. Data Availability Statement The data that supports the findings of this study are available in the supplementary material of this article. Supporting Information Filename Description anie74349-sup-0001-SuppMat.docx9 MB The authors have cited additional references within the Supporting Information [63-75].Supporting File 1: anie74349-sup-0001-SuppMat.docx.
LRP5-dependent transport of polyunsaturated fatty acids serves as an immune checkpoint for natural killer cells
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Editor’s summary Abstract INTRODUCTION RESULTS DISCUSSION MATERIALS AND METHODS Acknowledgments Supplementary Materials REFERENCES AND NOTES Information & Authors Metrics & Citations View Options References Figures Tables Media Share Editor’s summary Polyunsaturated fatty acids (PUFAs), such as omega-3s, are essential fatty acids that are obtained from the diet and support cardiovascular and brain function. PUFAs have contrasting, context-dependent effects on tumor progression and immunotherapy.
By Yi Luan, Defining STING activityBy, John Foley Verified, Chuan Kai Yang, Hongyue Zhou, Zhuo Chen, Ao Li, Peng Liu, Dianqing Wu, Wenwen Tang
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Science Magazine
Verified
Beyond the scaffold: Glia as architects of the neural extracellular matrix
Abstract REFERENCES AND NOTES Information & Authors Metrics & Citations Check Access References Figures Tables Media Share Abstract Astrocytes, oligodendrocyte lineage cells, and microglia dynamically shape the neural extracellular matrix (ECM) across brain development and aging. Recent findings highlight the potential of glial regulation of the ECM as a framework for understanding circuit formation and identify previously unrecognized targets in neurological diseases.
Defining STING activity
Abstract Highlighted Article Information & Authors Metrics & Citations View Options References Figures Tables Media Share Abstract Mapping mutations to cellular outcomes reveals the molecular mechanisms underlying STING activity.
Pancreatic Damage in Ovarian Cancer-Associated Cachexia Is Driven by Activin A Signalling
1 Introduction CAC is a complex, multifactorial metabolic disorder [1, 2] and a major contributor to morbidity and mortality in the advanced stages of various cancers, including pancreatic, gastric, oesophageal, lung, colorectal, liver, head and neck, ovarian, leukaemia, lymphoma and sarcoma [3-6]. Characterized by involuntary weight loss, CAC leads to severe frailty due to skeletal muscle atrophy, adipose tissue depletion and organ dysfunction [7, 8].
Primary Cilia Orchestrate Cardiac Pathogenesis: A Central Nexus of Remodeling, Signaling, and Repair
To the Editor, Cilia are conserved sensory antennae-like organelles that are microtubule-based and several micrometres in length. Cilia can receive external stimuli, such as light, chemicals, and mechanical forces, and transfer these signals to cells to initiate corresponding signalling pathways. Cilia can also transmit signals to recipient cells by secreting ectosomes. The functions of cilia are involved in organogenesis, embryonic patterning, and adult tissue homeostasis [1].
Remodeling of T-Tubules and Associated Calcium Handling Dysfunction in Heart Failure: Mechanisms and Therapeutic Insights
Keywords T-tubule remodeling Treatment Heart failure Calcium homeostasis Cardiomyocytes Get full text access Log in, subscribe or purchase for full access. References 1. Hong, T. ∙ Shaw, R.M. Cardiac T-Tubule Microanatomy and Function Physiol Rev. 2017; 97:227-252 2. Setterberg, I.E. ∙ Le, C. ∙ Frisk, M. ... The Physiology and Pathophysiology of T-Tubules in the Heart Front Physiol. 2021; 12, 718404 3. Abu-Khousa, M. ∙ Fiegle, D.J. ∙ Sommer, S.T. ...
Linear ubiquitination regulates the KSHV replication and transcription activator protein to control infection - Nature Communications
Abstract Like many other viruses, KSHV has two life cycle modes: the latent phase and the lytic phase. The RTA protein from KSHV is essential for lytic reactivation, but how this protein’s activity is regulated is not fully understood. Here, we report that linear ubiquitination regulates the activity of RTA during KSHV lytic reactivation and de novo infection. Overexpressing OTULIN inhibits KSHV lytic reactivation, whereas knocking down OTULIN or overexpressing HOIP enhances it.
Folliculotropic Mycosis Fungoides Is Associated with Decreased PD1 Staining Compared with Classic Mycosis Fungoides
1. Introduction Programmed cell death protein 1, recognized as PD-1 and CD279 (cluster of differentiation 279), is a protein present on the surface of T and B cells. It plays a crucial role in modulating the immune response in human cells by dampening the immune system’s activity and fostering self-tolerance through the suppression of T-cell inflammation.
Glucose metabolism disorder: a potential accomplice of SARS-CoV-2 - International Journal of Obesity
Cite this article Luan, Y., Luan, Y., He, H. et al. Glucose metabolism disorder: a potential accomplice of SARS-CoV-2. Int J Obes (2023).
Loss of WNT5 Proteins Reprograms Neutrophils in the Spleen to Provide Protection for DSS-Induced Colitis
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Lack of Fzd6 in Ciliated Cells Suppresses Ferroptotic Pulmonary Alveolar Cell Death Induced by LPS and Coronavirus
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LDL Receptor-Related Protein 5 is a Selective Transporter for Unesterified Polyunsaturated Fatty Acids
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Correction: Pazopanib Is a Potential Treatment for Coronavirus-Induced Lung Injuries
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Pazopanib Is a Potential Treatment for Coronavirus-Induced Lung Injuries
Abstract Severe acute respiratory syndrome coronavirus 2, responsible for the severe acute respiratory syndrome known as COVID-19, has rapidly spread in almost every country and devastated the global economy and health care system. Lung injury is an early disease manifestation believed to be a major contributor to short- and long-term pathological consequences of COVID-19, and thus drug discovery aiming to ameliorate lung injury could be a potential strategy to treat COVID-19 patients.
Pazopanib Is a Potential Treatment for Coronavirus-Induced Lung Injuries
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Sarm1 Gene Deficiency Attenuates Diabetic Peripheral Neuropathy in Mice
Complications Abstract Diabetic peripheral neuropathy (DPN) is the most common complication in both type 1 and type 2 diabetes, but any treatment toward the development of DPN is not yet available. Axon degeneration is an early feature of many peripheral neuropathies, including DPN. Delay of axon degeneration has beneficial effects on various neurodegenerative diseases, but its effect on DPN is yet to be elucidated.
Inhibitors of apoptosis protect the ovarian reserve from cyclophosphamide
CPA induces cell death, not cell proliferation. (A) Representative images (n = 3) of Ki67 staining in PD5 (72 h) or 8-week-old mouse ovary 1 day (24 h) after injection of PBS or 150 mg/kg CPA. Granulosa (orange) and somatic cells (red) were marked with arrows. Green = Ki67, blue = DAPI. Scale bar, 50 µm. (B) Representative images of TUNEL staining of PD5 CD-1 mouse ovary 1, 3 and 7 days after injection of 150 mg/kg CPA or PBS. Green = apoptotic cells, blue = DAPI. Scale bar, 50 µm.
Glatiramer Acetate Enhances Myeloid-Derived Suppressor Cell Function via Recognition of Paired Ig-like Receptor B
Glatiramer Acetate Enhances Myeloid-Derived Suppressor Cell Function via Recognition of Paired Ig-like Receptor B William van der Touw, Kyeongah Kang, Yi Luan, Ge Ma, Sunny Mai, Lihui Qin, Guanglin Bian, Ruihua Zhang, Sathish Kumar Mungamuri, Hong-Ming Hu, Cheng Cheng Zhang, Stuart A. Aaronson, Marc Feldmann, Wen-Chin Yang, Shu-Hsia Chen, Ping-Ying Pan The Journal of Immunology September 15, 2018, 201 (6) 1727-1734; DOI: 10.4049/jimmunol.1701450
Glatiramer Acetate Enhances Myeloid-Derived Suppressor Cell Function via Recognition of Paired Ig-like Receptor B
Glatiramer Acetate Enhances Myeloid-Derived Suppressor Cell Function via Recognition of Paired Ig-like Receptor B William van der Touw, Kyeongah Kang, Yi Luan, Ge Ma, Sunny Mai, Lihui Qin, Guanglin Bian, Ruihua Zhang, Sathish Kumar Mungamuri, Hong-Ming Hu, Cheng Cheng Zhang, Stuart A. Aaronson, Marc Feldmann, Wen-Chin Yang, Shu-Hsia Chen, Ping-Ying Pan The Journal of Immunology August 10, 2018, ji1701450; DOI: 10.4049/jimmunol.1701450
Glatiramer Acetate Enhances Myeloid-Derived Suppressor Cell Function via Recognition of Paired Ig-like Receptor B
Glatiramer Acetate Enhances Myeloid-Derived Suppressor Cell Function via Recognition of Paired Ig-like Receptor B William van der Touw, Kyeongah Kang, Yi Luan, Ge Ma, Sunny Mai, Lihui Qin, Guanglin Bian, Ruihua Zhang, Sathish Kumar Mungamuri, Hong-Ming Hu, Cheng Cheng Zhang, Stuart A. Aaronson, Marc Feldmann, Wen-Chin Yang, Shu-Hsia Chen, Ping-Ying Pan The Journal of Immunology August 1, 2018, ji1701450; DOI: 10.4049/jimmunol.1701450
Dendritic porous yolk@ordered mesoporous shell structured heterogeneous nanocatalysts with enhanced stability
One of the major challenges in heterogeneous catalysis is how to suppress the aggregation of thermodynamically unstable noble metal nanoparticles (NPs) and simultaneously maintain their high accessibility.
The synthesis of a bifunctional copper metal organic framework and its application in the aerobic oxidation/Knoevenagel condensation sequential reaction - Dalton Transactions (RSC Publishing)
A novel one-pot aerobic oxidation/Knoevenagel condensation reaction system was developed employing a Cu(II)/amine bifunctional, basic metal-organic framework (MOF) as the catalyst. The sequential aerobic alcohol oxidation/Knoevenagel condensation reaction was efficiently promoted by the Cu3TATAT MOF catalyst in the absence of basic additives. The benzylidenemalononitrile product was produced in high yield and selectivity from an inexpensive benzyl alcohol starting material under oxygen atmosphere.
Introduction of an organic acid phase changing material into metal-organic frameworks and the study of its thermal properties
The design and synthesis of a shape-stabilized composite phase change material (PCM) is the most practical approach for addressing the leaking issue of phase change materials. This manuscript describes a facile solution impregnating method to access a novel type of shape-stabilized PCM employing metal-organic frameworks as the matrix. A fatty acid@metal-organic framework (MOF) composite PCM for low temperature heat storage has been developed for the first time.
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