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Yi Sang on Muck Rack

Yi Sang

As seen in: Nature, MDPI, ACS Publications, The Nation, Poetry Magazine, The Paris Review, Guernica Mag, BOMB Magazine, The Offing, Litro
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Articles

An HDAC4-specific PROTAC degrader achieves radiation sensitization by enhancing ferroptosis in lung cancer

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By Chun Yu Cheng, Jiaxue Yang, Zhiliang Liu, fan zhang, Meng Yu, Ting Wang, Jianxin Huang, Li Wang, Tingxiu Xiang, Kaishun Hu, Yi Sang, Longhua Sun, Lingyan Qiu, Wei-Ping Min
| Nature Verified
Abstract Post-translational modifications (PTMs) play a critical role in cancer radioresistance, yet how they regulate ferroptosis to influence radiotherapy response remains poorly understood. Here, we show that HDAC4 promotes radiation resistance in lung cancer by inhibiting ferroptosis. Through a CRISPR screen in patient-derived organoids, we identify HDAC4 as a key mediator. Mechanistically, HDAC4 acts as an E3 SUMO ligase that SUMOylates MBD1, preventing its ubiquitination and degradation.
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Biogeochemical Controls on Wood Degradation as a Source of Bioavailable Carbon in Denitrifying Bioreactors

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By Yi Sang, Iva Petrovic, Lily Elaine DuPlooy, Zihao Zhang
| dx.doi.org
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Biogeochemical Controls on Wood Degradation as a Source of Bioavailable Carbon in Denitrifying Bioreactors

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By Yi Sang, Iva Petrovic, Zihao Zhang, Lily Elaine DuPlooy
| ACS Publications
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