Abstract Background: Triple-negative breast cancer (TNBC) is characterized by limited therapeutic options and frequent immune escape, while the molecular mechanisms linking tumor-intrinsic programs with antitumor immunity remain incompletely understood. Methods: LARP1 was identified through integrative analysis of TNBC transcriptomic datasets and RNA-binding protein databases, and its broader clinical and prognostic relevance was evaluated in the METABRIC breast cancer cohort.