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Yingxin Guan on Muck Rack

Yingxin Guan

As seen in: Frontiers in Immunology
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Articles

LARP1-mediated stabilization of CD73 mRNA promotes immune escape in triple-negative breast cancer

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By Xia Qiu, Jiying Shen, Liping Chen, Jiahao Wu, Siyuan Li, Yifan Gu, Yingxin Guan, Yibao Du
| Frontiers in Immunology
Abstract Background: Triple-negative breast cancer (TNBC) is characterized by limited therapeutic options and frequent immune escape, while the molecular mechanisms linking tumor-intrinsic programs with antitumor immunity remain incompletely understood. Methods: LARP1 was identified through integrative analysis of TNBC transcriptomic datasets and RNA-binding protein databases, and its broader clinical and prognostic relevance was evaluated in the METABRIC breast cancer cohort.
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