Yili Shen

Abstract Lung adenocarcinoma is one of the most common forms of lung cancer with a low five-year survival rate. The roles of the novel proteins and peptides encoded by circular RNAs (circRNAs) in cancer are emerging. However, the functions and underlying molecular mechanisms of the peptides that affect lung adenocarcinoma progression are yet to be elucidated. In this study, we characterized a lung-adenocarcinoma-associated small peptide (SCAPEP) encoded by circRNA_0065214 via the IRES element.

CONFLICT OF INTEREST STATEMENT All of the authors have contributed significantly to this work and have reviewed and approved this submission. None of the authors has any conflicts of interest to disclose. We have not submitted this work for publication elsewhere. Supporting Information Filename Description bph70220-sup-0001-Figure-S1.jpgJPEG image, 656.7 KB Figures S1. A. The expression level of circ PTK2 in GSE161348 and GSE146689. B. The back-splicing site confirmed by Sanger sequencing (left).