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Yin Chung

As seen in: Nature, BioRxiv, WARC, Hubbis
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Articles

Structural basis of GAIN domain autoproteolysis and cleavage-resistance in the adhesion G-protein coupled receptors

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By Fabian Pohl, Florian Seufert, Yin Chung, Robin schick, Björn Kieslich, Torsten Schöneberg, Tobias Langenhan, Peter Hildebrand, Norbert Sträter
| Nature Verified
Abstract The GAIN domain is a hallmark of adhesion G protein-coupled receptors (aGPCRs), as this extracellular domain contains an integral agonistic sequence (Stachel) that activates the receptor by binding to its 7-transmembrane helix (7TM) domain. Many aGPCRs undergo autoproteolytic cleavage at the GPCR proteolysis site (GPS), which has a canonical H-X-S/T sequence motif located within the GPCR autoproteolysis-inducing (GAIN) domain.
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Self-cleavage of the GAIN domain of adhesion G protein-coupled receptors requires multiple domain-extrinsic factors - Nature Communications

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By Yin Chung, Lina Zielke, Andrea Sinz
| Nature Verified
Abstract The autoproteolysis-inducing (GAIN) domain of class B2/adhesion G protein-coupled receptors (aGPCRs) is structurally conserved, and its self-cleavage is central to receptor mechanotransduction and signaling. Yet, the influence of factors beyond the protein fold on GAIN domain autoproteolysis remains unclear.
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In the Hubbis Hot Seat - Chung Yin O, Cone Marshall Group

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By Yin Chung, Chung Yin O, Antony Dirga, CHarles Martin, Charles Martin
| Hubbis
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