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Yin Hao Lee

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Articles

Angptl4 integrates dietary and microbial signals to disrupt gut barrier function in MASH

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By Damien Chua, Zun Siong LOW, Yin Hao Lee, Rattanaporn Kiatbumrung, Pornjira Somnark, Min Xu, Yue Shi, Gourav Kaushal, Aparna Mahadevan, Natalie Hooi, Mathan Raj, Ekaterina Sviriaeva, Beiming Cui, Shaun Tan, Kazuyuki Kasahara, Chun Loong Ho, Walter Wahli, Christine Cheung, Mintu Pal, Ru Zhong Zhang, Natthaya Chuaypen, Pisit Tangkijvanich
| Nature Verified
Abstract Metabolic dysfunction-associated steatotic liver disease (MASLD) is a major contributor to liver morbidity, yet mechanisms linking gut barrier dysfunction to early progression remains poorly defined. We identify intestinal angiopoietin-like 4 (Angptl4) as a central integrator of dietary and microbial signals that governs barrier integrity and hepatic oxidative stress, key early MASLD features.
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