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Yin-Hung Chu on Muck Rack

Yin-Hung Chu

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Melatonin potentiates estrogen therapy to prevent bone loss in an orchiectomy transfeminine mouse model

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By Pin-Keng Shih, Ya-Hsuan Chang, Wen-Chieh Liao, Chiung-Hui Liu, Yu-Yang Kao, Chi Hsiao, Yin-Hung Chu
| Nature Verified
Abstract Transfeminine individuals undergoing orchiectomy face an increased risk of early osteopenia and osteoporosis. Here, we investigated whether melatonin enhances estradiol (E2)-mediated skeletal protection after androgen deprivation using an orchiectomy plus E2 mouse model designed to mimic gender-affirming hormone therapy (GAHT). Bone architecture was assessed by micro-computed tomography (micro-CT) and histology.
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