Yin-Lin Wang

1 Introduction Trichodentoosseous syndrome (TDO, OMIM #190320) is a rare, autosomal dominant disorder affecting hair, teeth, and bones [1, 2]. Individuals with TDO are typically born with notably curly or kinky hair that may straighten over time. Both primary and permanent teeth exhibit thin (hypoplastic) and soft (hypomineralized) enamel, dentin hypoplasia, and taurodontism (enlarged and elongated pulp chambers), often leading to severe dental attrition and infection.

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1 INTRODUCTION Dental caries and myopia are two highly prevalent public health concerns that arise from family–lifestyle interactions. According to a systematic review from 1995 to 2019, the prevalence of caries in deciduous teeth and permanent teeth were 46.2% and 53.8%, respectively (Kazeminia et al., 2020). The American Academy of Ophthalmology had announced that the onset and the progression of myopia have become a global burden especially in East Asia (Modjtahedi et al., 2021).