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Receptor basis of unusual tissue tropism of avian influenza H5N1 clade 2.3.4.4b virus in cattle
Abstract INTRODUCTION RESULTS DISCUSSION MATERIALS AND METHODS Acknowledgments Supplementary Materials REFERENCES Information & Authors Metrics & Citations View Options References Figures Tables Media Share Abstract The unusual tropism of H5N1 clade 2.3.4.4b for cattle mammary glands, causing necrotizing mastitis without major respiratory involvement, raises critical questions about its underlying mechanisms.
Endothelial Cell Selectivity to Nanoparticles Depends on Mechanical Phenotype (Adv. Mater. Interfaces 18/2023)
Graphical Abstract Mechanotargeting of Atherogenic Endothelium In article number 202300137, Pouria Fattahi, Sulin Zhang, Peter J. Butler, and colleagues provide direct evidence for cell mechanics-based targeting of nanoparticles (NPs) to atherogenic endothelium, a drug-delivery strategy termed, mechanotargeting.
Endothelial Cell Selectivity to Nanoparticles Depends on Mechanical Phenotype
Uptake of NPs Correlates with Cell Morphology in an Atherogenic Mimetic Microfluidic System Endothelial cells exhibit morphological variability in vivo, especially at branches and regions of high curvature where the blood vessels are prone to plaque formation[15] (Figure 6a). In the previous sections, we showed that the accompanying mechanical characteristics of endothelial cells play a major role in nanoparticle uptake.
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