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Yin Xia Chao on Muck Rack

Yin Xia Chao

As seen in: Nature
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Articles

Identification of novel autoantibodies in Parkinson’s disease using a functional protein array platform

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By Yin Xia Chao, Bernett Lee, Muhammad Yaaseen Gulam, Jolene Tan, Anis Larbi, Lei Feng, Louis Tan, Jonathan Blackburn Verified, Eng-King Tan, Suh Yee Goh, Ee-Wei Lim, Kumar M. Prakash, Olaf Rötzschke
| Nature Verified
Abstract Autoimmunity has been implicated in Parkinson’s disease (PD), but the role of peripheral autoantibodies is unclear. Using a novel autoantibody screening platform (based on 3D protein structures), a 2-stage case-control study was conducted to identify peripheral autoantibodies in PD.
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Plasma Coenzyme Q10 Levels and Multiple System Atrophy

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By Yin Xia Chao
| JAMA (The Journal of the American Medical Association) Verified
To the Editor We read with interest the study by Mitsui and colleagues1 who found decreased levels of plasma coenzyme Q10 (CoQ10) in patients with multiple system atrophy (MSA) regardless of the COQ2 genotype. Mutations in CoQ2 (which encodes an essential enzyme in the biosynthetic pathway of CoQ10) have previously been shown to be associated with MSA.2 Mitsui et al1 found a lower plasma CoQ10 level in those with MSA compared with controls (95% CI, 0.10; range, 0.02-0.66) (P?=?.02).
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