Yina Sheng

1. Introduction Insulin-like growth factors (IGFs) induce a variety of bioactivities, including cell growth and survival in many cell types [1]. These bioactivities have linked the IGF signaling system with cancer risk, tumorigenesis, tumor growth, and survival [2,3,4]. In general, the binding of IGF to specific IGF-I receptors (IGFIR) on the plasma membrane activates its intrinsic tyrosine kinase activity [5,6].

Communication Sijin Liu, orcid.org/0000-0002-4628-9511 State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing, China These authors contributed equally to this work. Search for more papers by this author Biao Wang, State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing, China These authors contributed equally to this work.