Yinan Zhao
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A Lactate–H4K12la–HDAC1 epigenetic axis governs microglial state transitions during experimental autoimmune encephalomyelitis in female mice
Abstract Microglial functional plasticity is shaped by metabolic and epigenetic reprogramming, but how these processes regulate central nervous system autoimmunity remains unclear. We find that cerebrospinal fluid lactate levels correlate with multiple sclerosis severity. Using female mouse models of experimental autoimmune encephalomyelitis, spinal lactate accumulation drives persistent microglial histone lactylation, coupling to glycolytic activation.
In-situ transition zone supported bonding mechanisms and micromechanical assessment of IN718 LDED on C/SiC
ABSTRACT C/SiC ceramic matrix composites offer low density and excellent high-temperature stability, but reliable joining and repair remain challenging. In this study, powder-fed laser directed energy deposition (LDED) was used to fabricate a load-bearing IN718 layer directly on C/SiC, and the interfacial formation and load-transfer mechanisms were investigated.
The global impact of land reclamation on arbuscular mycorrhizal fungi depends on climate, vegetation type and agricultural management practices
CONFLICT OF INTEREST STATEMENT The authors have no relevant financial or non-financial interests to disclose. DATA AVAILABILITY STATEMENT The data used to support the findings of this study are available in ‘Figshare’. Data are available via Figshare. https://doi.org/10.6084/m9.figshare.30017947 (Wang, 2025). Supporting Information Filename Description jpe70341-sup-0001-Supinfo.docxWord 2007 document , 2.4 MB Table S1. Results for publication bias. Table S2.
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