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Yinan Zheng

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Articles

37-year-old man with hip pain after a fall

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By Yinan Zheng
| Aunt Minnie Verified
Home » Cases » 37-year-old man with hip pain after a fall CASE INSTRUCTIONS: Click the blue “Take this Case” button. This enrolls you to have access to the case. Alternatively, the button may say “Log in to Take this Case” or “Take this Course.” Click the blue “Start Case” button. This takes you into the Case. Alternatively, you can click the word “History.” Read the case history. The “History” section provides you with initial background information and may contain images relevant to the case.
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Developing a novel index for neighborhood social determinants of cardiovascular diseases in the CARDIA study

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By Tao Gao, Yinan Zheng, Brian Joyce, Lei Liu, Lili Liu, Catarina I. Kiefe, Sarah Forrester, Penny Gordon-Larsen, Chunyu Liu, Donald M. Lloyd-Jones, Kai Zhang, Lifang Hou
| Nature Verified
Abstract Neighborhood social determinants of health have been shown to influence cardiovascular risk and the development of cardiovascular disease, but few studies have been done about early-life exposure as well as the combined effect of multiple neighborhood social determinants of health measures.
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Epigenome-wide association study of nuclear DNA methylation in relation to mitochondrial heteroplasmy - Nature Communications

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By Meng Lai, Yinan Zheng, Christina A. Castellani, Mengyao Wang, Xue Liu, Tianxiao Huan, Kwadwo O. Bonsu, Wei Zhao, Roby Joehanes, Xiuqing Guo, JoAnn E. Manson, Joann Manson, Megan L. Grove, Jan Bressler, Tuuli Lappalainen, Nicole J Lake, Kendra R. Ferrier, Stephen Ekker, Charles Kooperberg, Patricia A. Peyser, Myriam Fornage, Laura M. Raffield, April P. Carson, Stephen S. Rich, Jerome I. Rotter, Jennifer Smith, Dan E. Arking, Chunyu Liu, NHLBI Trans-Omics, Kyler McKessy
| Nature Verified
Abstract We analyze 10,986 participants (mean age 77; 63% women; 54% non-White) across seven U.S. cohorts to study the relationship between mitochondrial DNA (mtDNA) heteroplasmy and nuclear DNA methylation. We identify 597 CpGs associated with heteroplasmy burden, generally showing lower methylation. These CpGs are enriched in dynamically regulated island shores and depleted in CpG islands, indicating involvement in context-specific rather than constitutive gene regulation.
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