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Persistent vision loss of eyes lost to follow-up with diabetic macular edema receiving intravitreal anti-vascular endothelial growth factor therapy
Keywords Diabetic macular edema Anti-vascular endothelial growth factor therapy Lost to follow-up Cohort study Persistent vision loss Introduction Diabetic retinopathy (DR) is the leading cause of blindness among working-age adults.1,2 Diabetic macular edema (DME) causes substantial vision loss in DR.3 Intravitreal injection of anti-vascular endothelial growth factor (VEGF) has revolutionized the primary care of DME and optimized visual outcomes.
Single-cell RNA-sequencing uncovers the dynamic changes of tumour immune microenvironment in advanced lung adenocarcinoma
Discussion The TME is a complex and dynamic evolving ecosystem during the initiation, development and metastasis of tumour.
Frontiers | Lineage tracing for multiple lung cancer by spatiotemporal heterogeneity using a multi-omics analysis method integrating genomic, transcriptomic, and immune-related features
1 Introduction Up to 20% of patients in screening populations are diagnosed with multiple lung cancer with synchronous or metachronous lung tumors, compared to a previous estimation that only 0.8%–4% of patients had multiple lesions (1). The identification of multiple pulmonary nodules raises a crucial clinical issue of whether multiple pulmonary nodules represent intrapulmonary metastasis (IPM) with a common origin or multiple primary lung cancer (MPLC) with independent lineages.
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