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Yinchi Chen

As seen in: Nature
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Articles

Schizophrenia and bipolar disorder risk gene AKAP11 sustains cognitive function by regulating TFEB-mediated autophagy

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By Zhiqiang Deng, Yuxuan Kan, Jia Liu, Yuxiao Yang, Xinjie Guan, Xiaogang Xu, Chengfu Su, JIng Lu, Kejia Lu, Jia-Hong Lu, Ashok Iyaswamy, Zhenyu Yue, Min Li, Yinchi Chen, Senthilkumar Krishnamoorthi, King-Ho Cheung, Ju-Xian Song
| Nature Verified
Abstract Schizophrenia (SCZ) and bipolar disorder (BD) share cognitive impairments and autophagy disruptions, with haploinsufficiency of AKAP11 (A-kinase anchoring protein 11) emerging as a major genetic risk factor for both disorders, though its functional role remains poorly understood.
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