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YinDi Zhu on Muck Rack

YinDi Zhu

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Articles

Complete biosynthesis of the clinical agent escin Ia

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By Huihua Wan, Mofan Zhang, Ranran Gao, Xuehua Xie, Weiqiang Chen, Xue Bo Cao, Wei Yang, Hui Yao, Chen Qin, Yi Zhang, Zhaohua Shi, Xiang Chen, Lichun Ye, Huiyuan Gao, Shilin Chen, Zhichao Xu, Wei Sun, Xiangxiao Meng, Songchun Guan, YinDi Zhu
| Nature Verified
Abstract Escin Ia is a barrigenol-type triterpenoid specific to Aesculus seeds and is widely utilized in clinical practice for the treatment of cerebral edema, swelling, and venous insufficiency. Here, we fully elucidated its biosynthetic pathway by identifying ten previously uncharacterized enzymes from Aesculus chinensis. AcCYP716BX1/2 catalyze the C-22α and C-28 hydroxylation of the β-amyrin scaffold, and AcCYP714E67 mediates the C-24 hydroxylation to produce protoaescigenin.
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