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Epigenetically Regulated NOX4/NRF2 Axis Mediates PM2.5-Induced Ferroptosis and Inflammatory Response in Membranous Nephropathy
1 Introduction Membranous nephropathy (MN) serves as a leading cause of nephrotic syndrome among middle-aged and elderly individuals (Zhang et al. 2026; Zand et al. 2026). The histological hallmark of this glomerular disease is immune-complex deposition and subsequent thickening of the glomerular basement membrane, which further activates the complement system in patients with MN (Sethi and Fervenza 2025; Radhakrishnan et al. 2024).
PML targets and resolves structured protein inclusions to mitigate neurodegeneration - Nature Cell Biology
Abstract Intranuclear inclusions are defining features of many neurodegenerative diseases, yet their assembly mechanisms and pathological roles remain poorly understood. Here, we investigate polyglycine (polyG) inclusions in neuronal intranuclear inclusion disease (NIID) and show that they recruit intrinsically disordered proteins to form stratified, immobile condensates that disrupt nuclear protein quality control and DNA damage repair.
Frontiers | Clinical efficacy of soft tissue micro-adjustment combined with traction in pediatric atlantoaxial subluxation: a randomised controlled study protocol using musculoskeletal ultrasound technology
1Tui Na Department, Hangzhou Hospital of Traditional Chinese Medicine, Hangzhou TCM Affiliated to Zhejiang Chinese Medicine University, Hangzhou, China 2Tui Na Department, Zhejiang Hospital, Hangzhou, China Background: Atlanto-axial rotatory subluxation (AARS) in pediatric patients is characterized by abnormal or restricted motion between the atlas and axis vertebrae, typically presenting with neck pain, limited mobility, torticollis, and muscle stiffness.
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