Yinfeng Zhang
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Wiley Online Library,
MDPI,
ACS Publications,
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Texas Medical Center
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Chemoproteomic profiling reveals histone H4 dopaminylation inhibiting cell growth
Abstract Dopaminylation, the covalent attachment of dopamine to the side chain of glutamine in proteins, represents a newly characterized class of posttranslational modifications. Because of the limited identification of substrates, the functions and molecular mechanisms associated with dopaminylation remain largely uncharacterized. Using an alkyne-functionalized dopamine probe, we developed a method for selectively enriching dopaminylated proteins in whole-cell systems.
Electrochemical Chemo- and Regioselective Reduction of Vicinal Diketones to α-Hydroxy Ketones Click to copy article link Article link copied!
Abstract Click to copy section linkSection link copied! α-Hydroxy ketones are valuable motifs in bioactive molecules and versatile synthetic intermediates, yet their selective preparation from vicinal diketones remains challenging due to issues of chemoselectivity, regioselectivity, and sustainability.
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