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Ying Ao

As seen in: Nature, MDPI, Science Magazine
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Articles

CK2α restriction of STING accumulation underlies systemic aging

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By Jie Zhang, Meiling Jin, Dan Rao, Ming Wang, Jing L. Wang, Canjie Ma, Baohua Liu, Zimei Wang, Ying Ao, Lanlan Rao, Yanzhen Mo
| Nature Verified
Abstract Chronic activation of the cGAS-STING pathway drives inflammaging and cellular senescence. Although nuclear envelope (NE) barrier failure leading to cytoplasmic chromatin leakage is a key trigger, the molecular mechanisms governing STING activity at the NE during aging remain poorly understood. Here, we identify lamin A/C (LMNA) as a critical NE scaffold that orchestrates STING regulation by recruiting both STING and Casein Kinase 2 (CK2α).
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Targeting CK2 eliminates senescent cells and prolongs lifespan in Zmpste24-deficient mice - Cell Death & Disease

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By Jie Zhang, Zhongjun Zhou, Baohua Liu, Ying Ao
| Nature Verified
Abstract Senescent cell clearance is emerging as a promising strategy for treating age-related diseases. Senolytics are small molecules that promote the clearance of senescent cells; however, senolytics are uncommon and their underlying mechanisms remain largely unknown. Here, we investigated whether genomic instability is a potential target for senolytic.
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Role of C-Terminal Phosphorylation of Lamin A in DNA Damage and Cellular Senescence

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By Ying Ao, Zhiwei Liao, Zhuping Wu, Juncong Lan
| MDPI
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