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Ying Cai

As seen in: Arthritis & Rheumatology, Color Research & Application, Emerging Infectious Diseases, Nature, Wiley Online Library, PLOS ONE, Elsevier, Frontiers in Immunology, MDPI, Science Magazine and
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Articles

Paclitaxel prodrug loaded high-density lipoprotein nanoparticles for chemoimmunotherapy of triple-negative breast cancer

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By Dong Deng, Xiao-Yu Zhang, Jia-meng Chen, Pei-Wen Jiang, Guan-Ru Wang, Ming-Hui Zhang, Han-Zhi Li, Ya-Ping Li, Ying Cai, Lin-yang Jiang, Bin-yu Zhu, Ling-li Zhou, Qing-min Yang, Yan-qiang Shan
| Nature Verified
Abstract Insufficient tumor-specific immunogenicity and cytotoxic T lymphocytes infiltration limit the therapeutic efficacy of combined chemotherapy and immune checkpoint blockade for triple-negative breast cancer (TNBC). To address this limitation, we developed a paclitaxel prodrug-loaded synthetic high-density lipoprotein nanoparticle (P-sHDL) that both targets tumors and induces immunogenic cell death (ICD) to potentiate immune checkpoint blockade.
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Vitamin D status, supplementation, and multiple sclerosis: a systematic review and meta-analysis

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By Yanyan Li Verified, Ying Xu, Xiaorui Pei, Ziqi Liu, Dan Gao, Lili Ma, Yan Wang, Yanan Fang, Ying Cai
| Frontiers in Immunology
Abstract Background: Multiple sclerosis (MS) is a chronic immune-mediated neurodegenerative disorder of the central nervous system and a leading cause of disability among young adults. The disease exhibits considerable heterogeneity in clinical progression, with some patients experiencing more aggressive disease activity and a rapid decline in quality of life.
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Atlas of predicted protein complex structures across kingdoms

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By Jianqiang Liang, Shimin Wen, Yuanyuan Li, Kai Ding, Junjie Fei, Weian Mao, Zhiyu Lin, Yichong Shen, Hongjie Zhu, Yayun Hu, Rui Zhang, Yafei Lu, Bonan Liu, Han Wang, Yuxuan Chen, Zhenguo Ma, Peiyuan Yang, Xinyu Xu, Junlong Wu, Youyuan Zhu, Wencheng Zhu, Shuya Li, Hongyi Xin, Daji Ergu, Jianyang Zeng, Zhi-Xiong Xiao, Chunhua Shen, Ying Cai, Yong Yi, Dacheng Ma, Xianzhi Qi, Yongfu Hao, Liupeng Li, Pengli Ji, Qiaosha Zou, Kelu Yao
| Nature Verified
Abstract Protein complexes are fundamental to all biological processes. Public repositories have expanded to include millions of potential protein–protein interactions (PPIs) from human and diverse model organisms. Yet, large-scale structural characterization of these complexes—especially across different biological kingdoms—has lagged far behind, leaving most potential and unidentified interactions unresolved.
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