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Ying Cai

As seen in: Arthritis & Rheumatology, Color Research & Application, Emerging Infectious Diseases, Nature, Wiley Online Library, arXiv, PLOS ONE, Elsevier, Frontiers in Immunology, MDPI and
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Articles

Targeting the γ-glutamylcysteine-ferroptosis axis protects diabetic podocytes by dual-regulation of SAT1 and SLC7A11/GPX4

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By Dandan Xie, Sifan Guo, Zhibo Wang, Xian Wang, Ying Cai, Chunsheng Lin, Qiqi Zhao, Yu Guan, Qiang Yang, Wenjie Sun, Yiqiang Xie, Aihua Zhang, Shi Qiu, Lasi Chen
| Nature Verified
Abstract Diabetic kidney disease (DKD) remains the leading cause of end-stage renal disease worldwide, yet the mechanisms driving its progression are poorly understood. Here, through integrated multi-omics analyses of clinical serum samples and db/db mice, we identified a marked depletion of the glutathione biosynthetic intermediate γ-glutamylcysteine (γ-GC), which demonstrated strong diagnostic potential (AUC = 0.986).
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Distributed Adaptive Probabilistic Event-Triggered Filtering for Fuzzy Systems Under Data-Important-Aware DoS Attack

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By Ying Cai, Zhidong Zhou, Jun Cheng
| Wiley Online Library Verified
1 Introduction Sensor networks (SNs) consist of spatially distributed smart sensor nodes deployed across specific regions to collaboratively collect, monitor, and process data. Recognized for their flexibility, scalability, and broad applicability in fields like environmental monitoring, industrial automation, and smart infrastructure [1, 2], SNs have attracted significant research interest and demonstrated considerable practical potential.
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Paclitaxel prodrug loaded high-density lipoprotein nanoparticles for chemoimmunotherapy of triple-negative breast cancer

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By Dong Deng, Xiao-Yu Zhang, Jia-meng Chen, Pei-Wen Jiang, Guan-Ru Wang, Ming-Hui Zhang, Han-Zhi Li, Ya-Ping Li, Ying Cai, Lin-yang Jiang, Bin-yu Zhu, Ling-li Zhou, Qing-min Yang, Yan-qiang Shan
| Nature Verified
Abstract Insufficient tumor-specific immunogenicity and cytotoxic T lymphocytes infiltration limit the therapeutic efficacy of combined chemotherapy and immune checkpoint blockade for triple-negative breast cancer (TNBC). To address this limitation, we developed a paclitaxel prodrug-loaded synthetic high-density lipoprotein nanoparticle (P-sHDL) that both targets tumors and induces immunogenic cell death (ICD) to potentiate immune checkpoint blockade.
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