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Ying-Chi Wang

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Articles

Architectural principles of the ribosomal large subunit revealed by A-helix spatial organization

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By Yi-Shan Lan, Jing-Hong Tu, Ying-Chi Wang, Chiaolong Hsiao
| Nature Verified
Abstract The ribosome, biology’s universal translation apparatus, is one of the deepest molecular imprints of life’s early evolution. Among its structural motifs, the RNA A-helix is the most abundant and fundamental architectural element. Here, we investigate how A-helices collectively shape the three-dimensional organization of the large ribosomal subunit (LSU) across bacteria, archaea, eukaryotes, and mitochondria.
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