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Ying-Chieh Kao on Muck Rack

Ying-Chieh Kao

As seen in: Nature
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Structural and biochemical basis for cannabinoid cyclase activity in marine bacterial flavoenzymes

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By Anna Love, Harshverdhan Sirohi, Felix Hubert, Daniel Quinnell, Tian Lan, Marissa Sheehy, Jonathan Hsu, Adrian Lee, Timothy S. Chang, Bruce A. Palfey, Geoffrey Chang, Bradley Moore, Ying-Chieh Kao, Ryan Gappy, Liana Zangwill
| Nature Verified
Abstract The marine bacterial flavoenzymes Clz9 and Tcz9 can process cannabigerolic acid to the minor cannabinoid, cannabichromenic acid (CBCA); however, the mechanistic details of this extrinsic transformation are still obscure. Here we report a thorough analysis of CBCA formation by Clz9 and Tcz9 through high-resolution crystallographic characterization, biochemical analysis and spectroscopic interrogation.
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