Ying-Chieh Lai

Conflicts of Interest The authors declare no conflicts of interest. Data Availability Statement All data were generated by the authors and are available upon request to the corresponding author of this study. Supporting Information Filename Description jmri70524-sup-0001-Figures.pdfPDF document, 1.2 MB Figure S1: Patient 1. Independently normalized measured pyruvate and lactate dynamics, inputless lactate fit, and pointwise 95% residual-bootstrap band.

Background Kidney transplant is the treatment of choice for patients with end-stage renal disease. Early detection of allograft injury is important to delay or prevent irreversible damage. Purpose To investigate the feasibility of hyperpolarized (HP) [1-13C]pyruvate MRI for assessing kidney allograft metabolism.

1. Introduction Colorectal cancer (CRC) has been the third most commonly diagnosed cancer and the second most deadly cancer in recent years. In 2020, CRC accounted for 10% of the global cancer incidence and 9.4% of cancer deaths. Due to the elevated exposure to environmental risk factors and lifestyles and diets shifting toward westernization, it is predicted that the number of new cases of CRC will reach 3.2 million in 2040 [].