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Ying Chieh Wu on Muck Rack

Ying Chieh Wu

As seen in: BioRxiv
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Articles

Human iPSC-derived pericyte-like cells carrying APP Swedish mutation overproduce beta-amyloid and induce cerebral amyloid angiopathy-like changes

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By Sarka Lehtonen, Ying Chieh Wu, Kalevi Trontti, Riitta Kauppinen
| BioRxiv
Abstract Alzheimer's disease (AD) patients often exhibit cerebral amyloid angiopathy (CAA), i.e beta-amyloid (Abeta) accumulation within cerebral blood vessels causing cerebrovascular dysfunction. Pericytes wrap around vascular capillaries, thus regulating cerebral blood flow, angiogenesis, and vessel stability. Vascular dysfunction can promote the development and progression of neurodegenerative diseases, yet the specific contribution of pericytes to AD pathology remains unclear.
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