Ying-da Song

1 INTRODUCTION Cancer is a significant global public health issue, with lung cancer having the highest incidence and mortality rates. According to the GLOBOCAN 2022 database, there was 2.5 million new cases in 2022, accounting for 12.4% of all new cancer cases. Globally, 1.8 million people succumb to lung cancer, constituting 18.7% of all cancer-related deaths.1 Exposure to risk factors for lung cancer has broadly changed with socioeconomic development and time.

Loading metrics Open Access Peer-reviewed Research Article Citation: Song Y-d, Bai X-m, Ma J (2024) The association of systemic immune-inflammation index with lung function, risk of COPD and COPD severity: A population-based study. PLoS ONE 19(6): e0303286. https://doi.org/10.1371/journal.pone.0303286 Editor: Stelios Loukides, National and Kapodistrian University of Athens, GREECE Received: January 20, 2024; Accepted: April 22, 2024; Published: June 14, 2024 Copyright: © 2024 Song et al.

INTRODUCTION Lung cancer, which accounts for 13% of all cancer cases and 23% of all cancer-related deaths worldwide, is the most common cause of cancer-related deaths globally and represents a primary public health problem worldwide.1 Cancer is a disease of older adults with more than 50% of malignancies diagnosed in patients over 65 years of age,2, 3 but the early-onset cancer incidence among people under age of 50 is increasing worldwide, showing a trend in the younger population.4 Fewer...