Ying-En Lee

1. Department of Pathology, Chi Mei Medical Center, Tainan, Taiwan. 2. Department of Pathology, E-DA Hospital, I-Shou University, Kaohsiung, Taiwan 3. Department of Anesthesiology, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan 4. Institute of Biomedical Sciences, National Sun Yat-sen University, Kaohsiung, Taiwan 5. Department of Oral and Maxillofacial Surgery, Chi Mei Medical Center, Tainan, Taiwan. 6.

CDKN3 expression is an independent prognostic factor and associated with advanced tumor stage in nasopharyngeal carcinoma 1. Department of Otolaryngology, Chi Mei Medical Center, Tainan, Taiwan 2. Department of Optometry, Chung Hwa University of Medical Technology, Tainan, Taiwan 3. Department of Pathology, Chi-Mei Medical Center, Tainan, Taiwan 4. Department of Anesthesiology, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan 5.

Purpose: Analysis of the nasopharyngeal carcinoma public transcriptome revealed JAK2 was significantly upregulated in tumors, which encouraged us to investigate its prognostic significance and mutational status. Materials & methods: We assessed the immune-expression of JAK2 and its relationships with various clinicopathological parameters. JAK2 mutation was detected by PCR followed by sequencing. Results: High expression of JAK2 was significantly associated with advanced tumor staging (p = 0.019).