Ying Gong
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PALLADIN regulates osteogenic differentiation of bone marrow mesenchymal stem cells and protects against bone loss in ovariectomized mice
Abstract Osteoporosis is a systemic skeletal disease associated with reduced bone density and impaired bone quality, which leading to a greater risk of fracture. The pathogenesis of osteoporosis is closely associated with compromised osteogenic differentiation of bone marrow mesenchymal stem cells (BMSCs). The actin-cytoskeleton associated protein PALLADIN has been reported to play a central role in the remodeling of the actin-cytoskeleton.
Dynamic S-palmitoylation of glioma-associated oncogene 1 regulates the incidence and progression of Sonic Hedgehog medulloblastoma
Abstract Aberrant activation of the Sonic Hedgehog (SHH)-glioma-associated oncogene 1 (GLI1) signaling pathway is a determinant driver of basal cell carcinoma (BCC) and SHH-subgroup medulloblastoma (MBSHH). Here, we demonstrate the role of S-palmitoylation and depalmitoylation of GLI1 in the regulation of incidence and progression of MBSHH.
Extracellular Vesicles of Streptococcus anginosus Mediate Gastritis via Epithelial Barrier Disruption and Macrophage‐driven Inflammation
1 Introduction Gastritis, characterized by inflammation of the gastric mucosa, is a common condition with diverse causes, including microbial infections, nonsteroidal anti-inflammatory drugs (NSAIDs), excessive alcohol consumption, autoimmune diseases, and stress [1]. Helicobacter pylori (H.
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