Ying Guan
Changhongjie
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Linear RAG scanning mediates editing of Igκ variable region repertoires
Abstract V(D)J recombination-mediated Igκ light chain variable region exon assembly in precursor (pre)-B cells involves recombination activating gene (RAG) endonuclease-orchestrated cleavage between and joining of paired Vκ and Jκ gene segments and flanking RAG-targeting recombination signal sequences (RSSs)1,2,3. The 3.1-megabase Igk contains 4 Jκs (Jκ1, 2, 4, 5) and 100-plus Vκs in clusters oriented for deletional or inversional joining2.
Quantitative evaluation of China's smart aging healthcare policy under the background of silver economy development: based on PMC model
Abstract Background: Against the backdrop of deep integration between population aging and digital technologies, smart aging care has emerged as a pivotal approach to alleviating caregiving pressures, optimizing resource allocation for senior care, and driving high-quality development of the silver economy.
Stillage-based reductive soil disinfestation with organic materials reshapes the microbiome of continuous tomato soil and suppresses Fusarium wilt
CONFLICT OF INTEREST The authors declare no conflict of interest. DATA AVAILABILITY STATEMENT All raw sequencing data used in this study had been deposited in the NCBI Sequence Read Archive (SRA) database under accession codes PRJNA1336432 (16S rRNA) and PRJNA1336436 (ITS). Supporting Information Filename Description ps70727-sup-0001-Figures.docxWord 2007 document , 10.1 MB Fig. S1. Rarefaction curves of the 16S rRNA (A) and ITS (B) gene amplicon reads. Colors represent different treatments.
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