Ying Hao
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Evaluation of cold tolerance in maize at the germination stage based on multivariate statistical methods
Abstract To investigate the cold tolerance of different maize varieties, in this study, an artificial climate chamber was used to simulate low-temperature stress conditions. During the germination stage, a control group (25 °C) and low-temperature treatment groups (12 °C, 10 °C, 8 °C, 6 °C) were established. Seven germination indicators were measured across 63 maize varieties, and cold-tolerant and cold-sensitive varieties were identified during the seedling stage.
Aromaticity at spike position 456 affects functional immunogenicity of SARS-CoV-2 Omicron variant receptor-binding domain
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Abstract The recurrent emergence of the F456L substitution in SARS-CoV-2 Omicron sublineages has been associated with immune evasion, yet its impact on vaccine-induced immune responses remains poorly understood. Using a trimeric RBD-HR subunit vaccine platform, we investigated how residue 456 influences the functional immunogenicity of the receptor-binding domain (RBD).
By Dandan Peng, Zimin Chen, Minyang Fu, Weiqi Hong, Mengzhe Dai, Hao Zeng, Sheng Yi Lin, Hong Lei, Jingyun Yang, Jie Shi, Xiya Huang, Chunjun Ye, Furong Qin, Yu Zhang, Ying Hao, Wenyan Ren, Li Chen, Jian Liu, Aqu Alu, Yishan Lu, Xinyi Du, Jiong Li, Huashan Shi, Yuquan Wei, Yi Chen, Shuaiyao Lu, Cai He, Guangwen Lu, Xiawei Wei, Binhan Wang
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Nature
Verified
APOE genotypes differentially remodel the astrocytic lipid droplet proteome to shape lipid droplet dynamics
Abstract Lipid droplets are dynamic cellular organelles that store neutral lipids and coordinate metabolic and stress-response pathways. In the brain, lipid droplets in glial cells, including astrocytes, have been implicated in Alzheimer’s disease, but how genetic risk factors influence their composition and turnover remains poorly understood. APOE is the strongest genetic modulator of late-onset Alzheimer’s disease and exists in common variants that confer decreased, neutral, or increased risk.
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