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Ying-Hua Cheng on Muck Rack

Ying-Hua Cheng

As seen in: Nature, Wiley Online Library, BioRxiv
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Articles

Inhibition of Tacrolimus Metabolism by Cannabidiol and Its Metabolites In Vitro

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By Gerald So, Ying-Hua Cheng, Debora L Gisch, Sachiko Koyama
| Wiley Online Library Verified
What is the current knowledge on the topic? ○ Case studies suggested the potential of a pharmacokinetic interaction between cannabidiol and tacrolimus, and in vitro studies have shown cannabidiol's inhibition on CYP3A4 and CYP3A5. However, this study uniquely investigates the effect of cannabidiol and its important metabolites on tacrolimus metabolism in vitro. What question did this study address?
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A Phase I Trial of the Pharmacokinetic Interaction Between Cannabidiol and Tacrolimus

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By Gerald So, Sachiko Koyama, Ying-Hua Cheng, Debora L Gisch
| Wiley Online Library Verified
WHAT IS THE CURRENT KNOWLEDGE ON THE TOPIC? Cannabidiol is a supplement used by over one in six Americans. It is an inhibitor of multiple cytochrome P450 (CYP) enzymes and potentially other proteins involved in drug disposition. Tacrolimus is a calcineurin inhibitor widely used in transplant recipients, has a narrow therapeutic range, and is subject to drug–drug interactions. WHAT QUESTION DID THIS STUDY ADDRESS?
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A MEF2C transcripton factor network regulates proliferation of glomerular endothelial cells in diabetic kidney disease

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By Ricardo Melo Ferreira, Debora L Gisch, Carrie Phillips, Ying-Hua Cheng
| BioRxiv
Abstract Background: The maintenance of a healthy epithelial-endothelial juxtaposition requires cross-talk within glomerular cellular niches. Neovascularization and nodular mesangial sclerosis are manifestations of dysregulated communication in diabetic kidney disease (DKD). We sought to understand the spatially-anchored regulation and transition of endothelial and mesangial cells from health to injury in DKD.
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