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Ying-Hung Lin

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Articles

Decreased Klotho Expression Causes Accelerated Decline of Male Fecundity through Oxidative Injury in Murine Testis

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By Ya-Yun Wang, Vin-Cent Wu, Yu-Hua Lin, Ying-Hung Lin
| MDPI
1. Introduction Infertility is a major health issue worldwide; approximately 7% of men suffer from infertility, affecting 10–15% of couples [1]. Moreover, the mean age of paternity has gradually increased over the past four decades. Advanced paternal age leads to decreased traditional semen quality, sperm DNA integrity, and pregnancy rates, further increasing the chances of birth defects and offspring diseases [2].
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