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Ying-jie Sun on Muck Rack

Ying-jie Sun

As seen in: Wiley Online Library, Royal Society of Chemistry
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Articles

A Conformational Restriction Strategy for the Control of CRISPR/Cas Gene Editing with Photoactivatable Guide RNAs**

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By Ying-jie Sun, Wen-Da Chen, Ji Liu, Jun-Jin Li
| Wiley Online Library Verified
Graphical Abstract We report on the discovery and development of conformationally restricted guide RNA, a head-to-tail cyclized molecule that can be easily prepared with only two or three modification sites. This is a superior approach for the spatiotemporal control of CRISPR/Cas editing, which has enabled the precise cleavage of exogenous genes at a predefined cutting region without notable editing leakages in live cells and in embryos.
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A photo-responsive chemical modulation of m6A RNA demethylase FTO

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By CAS Research, Ying-jie Sun, Li Ping Liu
| Royal Society of Chemistry Verified
A photo-responsive chemical modulation of m6A RNA demethylase FTO† The adenine N6-methylation m6A is a crucial modification that is associated with several biological functions. One of the two m6A demethylases FTO has arisen as an attractive target for the development of novel cancer therapies. Here, we describe a new design, synthesis and evaluation of a photo-responsive and selective inhibitor of FTO. You have access to this article Please wait while we load your content... Something went wrong.
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A Light‐Controllable Chemical Modulation of m6A RNA Methylation

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By Ying-jie Sun, Xiao-Yang Jin, Li-Jun Xie, li Liu
| Wiley Online Library Verified
Research Article Ling Lan, Beijing National Laboratory for Molecular Sciences (BNLMS), CAS Key Laboratory of Molecular Recognition and Function, CAS Research/Education Center for Excellence in Molecular Sciences, Institute of Chemistry, Chinese Academy of Sciences, Beijing, 100190 China University of Chinese Academy of Sciences, Beijing, 100049 China Search for more papers by this author Ying-Jie Sun, Beijing National Laboratory for Molecular Sciences (BNLMS), CAS Key Laboratory of Molecular...
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