Ying Lei
China
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Exploring biomarkers related to branched-chain amino acid metabolism in childhood obesity based on transcriptomics and experimental verification
Abstract Childhood obesity (CO) is a complex chronic disease driven by environmental, behavioral, and genetic factors. Dysregulation of branched-chain amino acid metabolism (BCAAM) contributes to CO development, highlighting the need to identify reliable biomarkers for diagnosis and treatment. Biomarkers associated with BCAAM remain largely unexplored in pediatric populations.
Topographic decoupling of tree-mortality disturbances drives contrasting soil carbon fates via divergent microbial strategies
Abstract Climate change is exacerbating tree mortality worldwide, threatening the stability of forest soil organic carbon (SOC) stocks. However, how SOC responds to tree mortality amid co-occurring disturbances remains mechanistically unresolved.
Association between intrinsic capacity and trajectories of physical function among older adults: findings from a 10-year longitudinal cohort study
Abstract Objectives: To identify trajectories of basic activities of daily living (BADL) and instrumental activities of daily living (IADL) and determine whether the baseline intrinsic capacity (IC) deficit score predicts 10-year functional decline in older adults. Methods: Data were from the Chinese Longitudinal Healthy Longevity Survey (2008–2018, N = 2,045). A six-domain IC deficit score was constructed using the Integrated Care for Older People (ICOPE) framework.
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