Ying-Li Luo

Functionalized cell membrane-coated nanoparticles induce local immune tolerance for durable survival of allogeneic islet grafts Allogeneic islet transplantation is a promising therapeutic strategy for type 1 diabetes (T1D). However, establishing durable immune tolerance to protect engrafted islets without systemic immunosuppression remains a major challenge.

Dually Regulating the Proliferation and the Immune Microenvironment of Melanoma via Nanoparticle-Delivered siRNA Targeting Onco-Immunologic CD155 Studies have demonstrated that simultaneous regulation of tumor cell proliferation and suppressive tumor immune microenvironment (TIME) could achieve better therapeutic effects. However, the targets of the proliferation and the TIME are different, which greatly limits the development of cancer therapy.

Message RNA-based vaccines, with their prominent advantages such as facile production, no requirement for nuclear entry and high safety without the need of integration into the host genome, have shown to be potent activators of the cytotoxic immune system. However, the wider application of mRNA-based therapeutics has been hindered because of their intrinsically high vulnerability to expressed nucleases and difficulty to enter antigen-presenting cells (APCs) directly.