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Discovery and Optimization of AMT-676, a CDH17-Targeting ADC for the Treatment of Advanced Gastrointestinal Cancers
1 Introduction Gastrointestinal (GI) cancers encompass a heterogeneous group of diseases affecting the digestive system, including esophageal cancer, gastric cancer (GC), hepatocellular carcinoma, pancreatic cancer, biliary tract cancer (BTC), colorectal cancer (CRC), anal cancer, and neuroendocrine tumors (NETs) [1]. These cancers are prevalent worldwide and account for a significant proportion of cancer-related deaths globally.
Abstract 4242: Systematic transcriptome analysis of small cell carcinoma of esophagus suggests a possibility for immunotherapy
Bioinformatics, Convergence Science, and Systems Biology Qi Zhao, Yan-xing Chen, Ying-nan Wang, Qi-nian Wu, Hui Sheng, JIa-jia Hu, Yun-xin Lu, Ze-xian Liu, Zhi-xiang Zuo, Feng Wang and Rui-hua Xu DOI: 10.1158/1538-7445.AM2019-4242 Published July 2019 Proceedings: AACR Annual Meeting 2019; March 29-April 3, 2019; Atlanta, GA Abstract Background/Aims: Small cell carcinoma of the esophagus (SCCE) is a rare and highly deadly malignancy with rapid disease progress and extensive metastasis, whereas...
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