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Atrial-specific LKB1 knockout mice and validation in human atrial tissue reveal that lysine propionylation of OXCT1 is associated with atrial fibrillation
Abstract Atrial fibrillation (AF), the most prevalent clinical arrhythmia, imposes a major global health burden through elevated risks of stroke, heart failure, and mortality. Lysine propionylation (Kpr) is mainly involved in metabolic regulation and plays an important role in cardiac pathophysiology. However, the specific role and mechanism of Kpr in AF remain unclear.
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