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Ying Sheng on Muck Rack

Ying Sheng

As seen in: Nature, Wiley Online Library, arXiv, Frontiers, MDPI, ACS Publications, Royal Society of Chemistry, BioRxiv
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Articles

E3 ligase LMO7 promotes ALKBH2 ubiquitination to sensitize MGMT-deficient glioblastoma to temozolomide

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By Zhiming Sun, Yue Liu, Liyuan Zeng, Ye Liu, Zhaohui Liu, Jiabing Li, Ying Sheng, Yu Zhao, Yunfang Deng, Chujing He, Yuqiao Cai, Yuyao Xue
| Nature Verified
Abstract Temozolomide (TMZ) resistance in glioblastoma (GBM) is often linked to high MGMT protein levels, but MGMT-deficient tumors can still acquire resistance, implicating MGMT-independent repair pathways. Here, we identify an oxidative stress-responsive LMO7–ALKBH2 ubiquitination mechanism that regulates ALKBH2 stability and modulates alkylation damage tolerance in GBM.
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DeepSeek-V4 on Day 0: From Fast Inference to Verified RL with SGLang and Miles

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By Tom Chen, Ying Sheng, Mingyi Lu
| lmsys.org
The SGLang and Miles TeamApril 25, 2026 We are thrilled to announce Day-0 support for DeepSeek-V4 across both inference and RL training. SGLang and Miles form the first open-source stack to serve and train DeepSeek-V4 on launch day — with systems purpose-built for its hybrid sparse-attention architecture, manifold-constrained hyper-connections (mHC), and FP4 expert weights. Figure 1. Decode throughput of SGLang vs the other OSS engine on a 30K-token prompt truncated from "Dream of the Red Chamber".
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Adaptive Incorporation of External Summary Information in the Cox Regression Under Population Heterogeneity

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By Yiqi Li, Yuan Huang, Ying Sheng, Qingzhao Zhang
| Wiley Online Library Verified
Conflicts of Interest The authors declare no conflicts of interest. Data Availability Statement The brain tumor data used in this article are available in the public domain: https://seer.cancer.gov. The interpretation and reporting of the brain tumor data are the sole responsibility of the authors. The authors acknowledge the efforts of the National Cancer Institute and the Surveillance, Epidemiology, and End Results Program tumor registries.
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