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Mycotoxin Alternariol Induces Ca2+ Dysregulation and Cell Death in Astrocytes: Mechanistic Toxicological Insights
Conflicts of Interest The authors declare no conflicts of interest. Data Availability Statement The data that support the findings of this study are available from the corresponding author upon reasonable request. References , , , and . 2021. “Alternaria Toxins—Still Emerging?” Comprehensive Reviews in Food Science and Food Safety 20, no. 5: 4390–4406. https://doi.org/10.1111/1541-4337.12803. , and . 2017.
Investigation of the mechanisms behind ochratoxin A‐induced cytotoxicity in human astrocytes and the protective effects of N‐acetylcysteine
CONFLICT OF INTEREST STATEMENT None of the authors have any conflicts of interest related to this manuscript. REFERENCES , , , & (1994). Ochratoxin A production by strains of Aspergillus niger var. niger. Applied and Environmental Microbiology, 60(7), 2650–2652. https://doi.org/10.1128/aem.60.7.2650-2652.1994 , , & (1991). Mitochondrial dysfunction is an early event in ochratoxin A but not oosporein toxicity to rat renal proximal tubules. Toxicology and Applied Pharmacology, 107(1), 73–80.
High Thioredoxin Domain-Containing Protein 11 Expression Is Associated with Tumour Progression in Glioma
1. Introduction Glioblastoma (GBM) is a devastating and intractable type of brain cancer. It is the most common malignant central nervous system (CNS) tumour, with a prevalence of 3.23 per 100,000 people and a 5-year survival rate of only 7.2% in the United States [1]. Even with current multimodal treatment that involves maximal safe surgery, radiotherapy, and chemotherapy, the median survival is still less than 2 years [2,3].
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