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Stereoselective Synthesis of 2-Deoxyglycosides: An Efficient Protocol for Alcohol Deoxygenation
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DMAP-promoted oxidative functionalization of α-amino ketones via oxygen delivery from water/alcohols
DMAP-promoted oxidative functionalization of α-amino ketones via oxygen delivery from water/alcohols† This paper shows a novel oxidative functionalization of α-amino ketones to yield the corresponding α-ketoamides and α-acylimidates. The reaction proceeds via oxygen delivery from water/alcohols in conjunction with an electron acceptor and 4-dimethylaminopyridine (DMAP). Mechanistic study indicates that DMAP exhibits a dual function of nucleophilic catalysis and proton abstraction.
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