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Paraventricular thalamus‐insular cortex circuit mediates colorectal visceral pain induced by neonatal colonic inflammation in mice
1 INTRODUCTION The prevalence of chronic colorectal visceral pain in clinical practice is as high as 10%–25%.1 Irritable bowel syndrome (IBS) is a common functional gastrointestinal disorder characterized by visceral pain, abdominal bloating, and abnormal bowel movements.2, 3 The incidence of IBS has been increasing in recent years,4 whereas the etiology of IBS is not completely understood, which prevents effective treatments and thus makes a negative impact on the physiological and...
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