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CDDO regulates central and peripheral sensitization to attenuate post‐herpetic neuralgia by targeting TRPV1/PKC‐δ/p‐Akt signals
1 INTRODUCTION Dysfunction of central or peripheral nervous system following nerve injury due to acute events or systemic disease induces neuropathic pain.1 Postherpetic neuralgia (PHN) is a notorious neuropathic pain that can last for months to years, which features persistent profound mechanical allodynia and spontaneous pain.2 Around 10%–35% of patients who recover from herpes zoster virus infection suffer from this severe complication.3 It typically occurs in elderly and results in...
Migraines and keloids: a 15-year Taiwan claim database analysis
Discussion After adjusting for these covariates, the results of this study suggest that the keloids group were more likely to develop migraine compared with the non-keloids group. However, the keloids group had a higher prevalence of comorbidities. Additional stratification analysis revealed that patients younger than 50 years had a significantly higher migraine risk compared with their older counterparts, which demonstrated that early onset of keloids increased the risk of migraine.
Migraines and keloids: a 15-year Taiwan claim database analysis
Migraines and keloids: a 15-year Taiwan claim database analysis http://orcid.org/0000-0001-7227-2345Ying-Yi Lu1,2,3, Hao Qin4, Chun-Ching Lu5, Ming-Kung Wu6, Cong-Liang Zhang7, http://orcid.org/0000-0001-5116-8004Chieh-Hsin Wu8,9 1Department of Dermatology, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan 2Shu-Zen Junior College of Medicine and Management, Kaohsiung, Taiwan 3Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan 4Department...
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