Ying Yin
Chongqing
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Targeting BIRC6 rejuvenates hematopoietic stem cell aging and immunosenescence
Abstract Immunosenescence represents a central hallmark of organismal aging, characterized by a progressive decline in immune function, which compromises host defense and accelerates systemic aging. Hematopoietic stem cell (HSC) aging is a key contributor to this process, characterized by aberrant expansion, myeloid-biased differentiation, and impaired self-renewal, culminating in hematopoietic-immune imbalance.
Vision impairment and cognitive function in Chinese older adults with diabetes: multiple mediating effects of social participation and perceived control
Abstract Background: Vision impairment and cognitive decline are common concerns among older adults with diabetes. Although visual difficulties have been associated with poorer cognitive function, the social and psychological pathways underlying this association remain insufficiently understood.
Bmi1 is a key effect molecule of p27-Shh signal pathway in mouse alveolar bone formation
Abstract Previous studies have suggested that Bmi1 is a positive regulator of osteoblast formation and osteogenesis, while p27 is a negative regulator. Mice lacking p27 display larger mandibles which accompanied with the upregulated Bmi1.
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