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Psychological and quality of life outcomes associated with multikinase inhibitors versus immune checkpoint inhibitors in advanced hepatocellular carcinoma | Scientific Reports
Abstract To compare the effects of multikinase inhibitors (sorafenib/lenvatinib) and immune checkpoint inhibitors (PD-1/PD-L1) on anxiety, depression, and quality of life (QoL) in patients with advanced hepatocellular carcinoma (HCC) and to analyse their correlations with clinical indicators. This retrospective cohort study included 304 patients with advanced HCC (BCLC stage B/C) who received first-line monotherapy between 2018 and 2023.
Effects of Interactive Handgrip Game on Vascular Maturation and Grip Strength in Patients Undergoing Arteriovenous Fistula Surgery: A Feasibility Randomized Controlled Trial
Conflicts of Interest The authors declare no conflicts of interest. Data Availability Statement The data that support the findings of this study are available from the corresponding author, upon reasonable request. References 1, , , et al., “Global Epidemiology of End-Stage Kidney Disease and Disparities in Kidney Replacement Therapy,” American Journal of Nephrology 52, no. 2 (2021): 98–107.
Recent advances of organelle-targeted fluorescent probes for hydrogen peroxide
Recent advances of organelle-targeted fluorescent probes for hydrogen peroxide Hydrogen peroxide (H2O2), a critical product of oxygen metabolism, serves as a key signaling molecule in diverse biological processes, including immune responses and cellular signal transduction. However, the direct detection of H2O2 remains challenging due to its short half-life and the ubiquitous presence of antioxidants in biological systems.
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